Being a health care professional in the ICU serving patients with covid-19: A qualitative studyResearch article Published on 2023-01-012022-10-05 Journal: Heart & lung : the journal of critical care [Category] 치료기술, [키워드] Anxiety approach being Care conducted COVID-19 COVID-19 pandemic Experiences explain Health health care providers Healthcare provider hospitalized patient ICU Infectious disease information intensive care intensive care unit Invasion management Nurse objective pandemic Pandemics participant Patient physical Physicians Psychological receive recruit Research Result risk the epidemic Turkey with COVID-19 [DOI] 10.1016/j.hrtlng.2022.07.011 [Article Type] Research article
Statistical analysis supports UTR (untranslated region) deletion theory in SARS-CoV-2Article Published on 2022-12-012022-11-16 Journal: Virulence [Category] COVID19(2023년), SARS, 변종, [키워드] affected Analysis ancestor Asymptomatic asymptomatic patients clinical outcomes correlation Degradation deletion of the untranslated region demonstrated Deterioration driving early stage evaluate Evolution explain genetic influence Genome hospitalized patient indicated mathematical Mortality mortality rate Mutation nucleic acid nucleic acid degradation system Patient SARS-CoV-2 SARS-COV-2 infection significantly significantly more similarity strain Support Symptoms the epidemic Toxicity UTR viral genome viral toxicity viral toxicity. virulence virus virus genome was performed [DOI] 10.1080/21505594.2022.2132059 PMC 바로가기
Skin capillary alterations in patients with acute SarsCoV2 infectionArticle Published on 2022-12-012022-11-16 Journal: Journal of hypertension [Category] COVID19(2023년), SARS, 치료기술, [키워드] A significant reduction acute infection acute phase addition alteration Angiogenesis Autopsy blood chemistry C-reactive protein capillary complications correlation COVID-19 demonstrated discharge endothelial damage Endothelial dysfunction Endothelitis evaluated events Evidence explain hospital impairment incidence increase in Infection Inflammation Inflammatory marker inverse correlation Ischemia lymphocyte material oedema organ parameter Patient patients procoagulant promote repeated resulting skin the disease thrombosis tissue vascular effect vasoconstriction viral infection with COVID-19 [DOI] 10.1097/HJH.0000000000003271 PMC 바로가기
Coronavirus disease 2019 subphenotypes and differential treatment response to convalescent plasma in critically ill adults: secondary analyses of a randomized clinical trialArticle Published on 2022-11-012022-11-15 Journal: Intensive care medicine [Category] Fulltext, MERS, 바이오마커, [키워드] ABO-compatible convalescent plasma Adaptive platform trial Adults analysis assigned Biomarker Biomarkers chemokines community-acquired pneumonia convalescent plasma Convalescent plasma therapy coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critically ill critically ill patients Cytokines difference effector immune responses elevated endothelial explain heterogeneous homogeneous Hypothesis immunologically immunotherapies Inflammation IQR median multifactorial organ support outcome outcomes patients Population precision medicine Prevalence Randomized randomized clinical trial RCT RCTs REMAP-CAP reported secondary analysis Subphenotypes. tested therapy treatment effect Treatment response usual care with COVID-19 [DOI] 10.1007/s00134-022-06869-w PMC 바로가기
Critical pediatric neurological illness associated with COVID-19 (Omicron BA.2.3.7 variant) infection in Taiwan: immunological assessment and viral genome analysis in tertiary medical centerArticle Published on 2022-11-012022-11-16 Journal: International Journal of Infectious Diseases [Category] SARS, 변종, [키워드] Amino acid amino acid variation cause cerebrospinal fluid children collected Complication COVID-19 COVID-19 infection diagnosed Encephalitis Epidemic explain immunological incidence increase in Infection Inflammatory marker Lineage medical record Mutation N-terminal domain nasal swab neurological Neurological complication Neurological symptom Neurological symptoms omicron Patient pediatric pediatric cases Pediatric patient Pediatric patients positive Protein reported SARS-CoV-2 sequence Sequencing Severe neurological symptoms spike Spike protein Strains Taiwan tested the S protein variant Variation viral genome analysis whole genome Whole genome sequencing whole genome sequencing. with COVID-19 [DOI] 10.1016/j.ijid.2022.09.001 PMC 바로가기
Spatiotemporal clusters and the socioeconomic determinants of COVID-19 in Toronto neighbourhoods, CanadaResearch article Published on 2022-11-012022-10-05 Journal: Spatial and spatio-temporal epidemiology [Category] 진단, 치료기술, [키워드] affecting Canada Cluster Clustering analysis COVID-19 determinant driver effective epidemiological explain identify Intervention Local Multiscale geographically weighted regression (mgwr) predictor Regression model regression models Space-time clusters Spatial regression spatiotemporal Toronto variable were used [DOI] 10.1016/j.sste.2022.100534 [Article Type] Research article
SARS-CoV-2 cell entry beyond the ACE2 receptorArticle Published on 2022-11-012022-11-16 Journal: Molecular biology reports [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 expression ACE2 receptor AGTR2 ASGR1 Asymptomatic auxiliary B.1.1.529 B.1.1.7 B.1.617.1 B.1.617.2 binding carried CD147 CD26 cell entry cell surface receptors CLEC4G Cochrane Library COVID19 Delta Delta+ develop English enzyme erythrocyte Evidence explain facilitate host cell Hypoxemia Infection KREMEN1 LDLRAD3 membrane protein MeSH term neuropilin omicron organs Protein receptor receptors S protein SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2. SARSCoV-2 selected target therapeutic agent tissue tropism TMEM30A Transmission variants of SARS-CoV-2 viral entry virus entry [DOI] 10.1007/s11033-022-07700-x PMC 바로가기
SUMMIT: An integrative approach for better transcriptomic data imputation improves causal gene identificationArticle Published on 2022-10-252022-11-16 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] Accuracy analysis approach association Blood build complex component COVID-19 severity dataset eQTL etiology explain expression Gene Expression Genetic Genome-wide association study identify IMPROVE loci low expression modeling moderate proportion provided Quantitative regulated severity Simulation study Statistical power traits transcriptome-wide transcriptomic data with COVID-19 [DOI] 10.1038/s41467-022-34016-y PMC 바로가기
Reduced B cell antigenicity of Omicron lowers host serologic responseArticle Published on 2022-10-182022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Antibody Response Antibody titer antigenicity B cell Breakthrough infection common cold coronavirus computational structural biology conserved CP: Immunology CP: Microbiology cross-reactivity deep learning ELISA Epitopes evade explain feature geometric Host Infection less Lower mechanism Mice immunization experiment mutated Neutralizing omicron Omicron variant of concern RBD RBS Receptor binding Receptor binding domain receptor binding site reduced reduction reduction in reveal SARS-CoV-2 Serologic response serological response serum Spike protein spike protein. trajectory vaccine-induced antibody variant variants viral evolution [DOI] 10.1016/j.celrep.2022.111512 PMC 바로가기
Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2Article Published on 2022-10-182022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ADE antibody Antibody-dependent enhancement antibody-dependent enhancement (ADE) complex countermeasures explain feeble immune Immune cell immune system in vivo internal environment Interpretation mechanism multiple roles of macrophages Mutant strains neutralize patients Perspective receptor-mediated. reduced SARS-CoV-2 SARS-COV-2 infection shown specific antibody virus [DOI] 10.3389/fimmu.2022.1008285 PMC 바로가기